A new study published in Cell Reports has investigated how exposure to certain triggers can increase the risk of type-1 diabetes.
Researchers from The Westmead Institute for Medical Research in western Sydney are looking at an array of potential triggers that could increase the risk of type-1 diabetes. Results of a recent study have shown how exposure to coxsackievirus can increase this risk.
What is coxsackievirus?
Coxsackievirus is a common virus that causes diseases including myocarditis, hand, foot and mouth disease, and gastroenteritis.
The study discovered that a key transcription factor (proteins that help turn specific genes on or off) called hypoxia inducible factor 1-alpha (HIF-1A) is behind this increase in risk. Researchers found that mice missing HIF-1A in beta cells (β-cells) had a much higher risk of type-1 diabetes after infection with viruses, including coxsackievirus.
Lack of β-cell HIF-1A increased β-cell death and, in turn, increased the incidence of type-1 diabetes.
‘Recover or die’
Lead researcher Professor Jenny Gunton says the findings highlight the key role β-cells play in the risk of diabetes.
“If they are healthy, then β-cells recover normally after stresses like viral infections, and diabetes does not develop,” she said. “But, if β-cells don’t cope well with these stresses, it can trigger the immune process that leads to type-1 diabetes.
“Our study also showed that the increase in diabetes risk can result from exposure to other stresses, including toxins. So β-cells play a crucial part in preventing their own death when faced with environmental triggers for type-1 diabetes.
“We have now identified that HIF-1A as an important factor in this ‘decision’ about whether the cells recover or die. This is the first β-cell specific model to show increased risk of type-1 diabetes with a range of triggers.”
Pathway to prevention?
The findings highlight HIF-1A as a potential pathway for the development of new preventative measures and suggest the possibility that a vaccine for coxsackievirus could help prevent type-1 diabetes in at-risk people.
“While there is a strong genetic component to type-1 diabetes, genes alone cannot explain the rising global rates of type-1 diabetes,” Professor Gunton said.
“Currently, the only cures for type-1 diabetes are whole-pancreas or islet transplantation, and people have to take insulin for the rest of their lives. So potential preventative strategies are exciting.”