Anxiety could be eased by regulating gut bacteria

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People who experience anxiety symptoms might be helped by taking steps to regulate the microorganisms in their gut using probiotic and non-probiotic food and supplements, suggests a review of studies published today in the journal General Psychiatry.

Anxiety symptoms are common in people with mental diseases and a variety of physical disorders, especially in disorders that are related to stress.

Previous studies have shown that as many as a third of people will be affected by anxiety symptoms during their lifetime.

Gut feeling

Increasingly, research has indicated that gut microbiota – the trillions of microorganisms in the gut that perform important functions in the immune system and metabolism by providing essential inflammatory mediators, nutrients and vitamins – can help regulate brain function through something called the “gut-brain axis”.

Recent research also suggests that mental disorders could be treated by regulating the intestinal microbiota, but there is no specific evidence to support this.

Therefore, a team of researchers from the Shanghai Mental Health Center at Shanghai Jiao Tong University School of Medicine, China, set out to investigate if there was evidence to support improvement of anxiety symptoms by regulating intestinal microbiota.

They reviewed 21 studies that had looked at 1,503 people collectively.

Of the 21 studies, 14 had chosen probiotics as interventions to regulate intestinal microbiota (IRIFs), and seven chose non-probiotic ways, such as adjusting daily diets.

Probiotics are living organisms found naturally in some foods that are also known as “good” or “friendly” bacteria because they fight against harmful bacteria and prevent them from settling in the gut.

Positive effect

The researchers found that probiotic supplements in seven studies within their analysis contained only one kind of probiotic, two studies used a product that contained two kinds of probiotics, and the supplements used in the other five studies included at least three kinds.

Overall, 11 of the 21 studies showed a positive effect on anxiety symptoms by regulating intestinal microbiota, meaning that more than half (52 per cent) of the studies showed this approach to be effective, although some studies that had used this approach did not find it worked.

The researchers conclude: “We found that more than half of the studies included showed it was positive to treat anxiety symptoms by regulation of intestinal microbiota.

“There are two kinds of interventions (probiotic and non-probiotic interventions) to regulate intestinal microbiota, and it should be highlighted that the non-probiotic interventions were more effective than the probiotic interventions.

“More studies are needed to clarify this conclusion since, we still cannot run meta-analysis so far.”

They also suggest that, in addition to the use of psychiatric drugs for treatment, “we can also consider regulating intestinal flora to alleviate anxiety symptoms.”